Adsorption of anti-dsDNA antibodies by immobilized polyanionic compounds
نویسندگان
چکیده
منابع مشابه
ANTI-dsDNA ANTIBODIES AND LUPUS NEPHRITIS
NEPHRITIS Antibodies against DNA were described in 1957 by four independent research groups (1–4). Scientists at that time could not foresee that the discovery of antibodies to double-stranded DNA (dsDNA) would have an immense impact on our understanding of origin and regulation of autoimmunity in general, and more specifically on autoimmunemediated inflammation. Soon after their discovery, it ...
متن کاملComplement fixation by anti-dsDNA antibodies in SLE: measurement by radioimmunoassay and relationship with disease activity.
We have developed a sensitive, solid phase radioimmunoassay (RIA) to quantify the amount of complement (C') fixation by anti-double-stranded DNA (anti-dsDNA) antibodies and have studied sera from 48 patients with systemic lupus erythematosus (SLE). 46% of the patients were positive in this assay. There was no correlation with serum C' levels, and only weak correlation with anti-dsDNA activity a...
متن کاملAnti-C1q, anti-chromatin/nucleosome, and anti-dsDNA antibodies in juvenile systemic lupus erythematosus patients.
OBJECTIVES To evaluate the presence of anti-C1q, anti-chromatin/nucleosome and anti-double stranded DNA (dsDNA) antibodies in juvenile systemic lupus erythematosus (JSLE) and controls. METHODS Sixty-seven JSLE and 34 healthy controls were analyzed for the presence of anti-C1q, anti-chromatin/nucleosome, and anti-dsDNA antibodies by ELISA. C1q levels were evaluated by radial immunodiffusion. ...
متن کاملThe emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice.
Nucleosome (NS)-reactive autoantibodies appear to be involved in the pathogenesis of systemic lupus erythematosus (SLE), but the mechanisms responsible for their production remain elusive. To study whether antibodies specific to NS are present prior to anti-double-stranded (ds) DNA antibodies in lupus mice, ELISA was carried out using the plates which had been confirmed to be coated with compar...
متن کاملAnti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis.
BACKGROUND Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial. OBJECTIVE To study the immunological and demographic factors associated with the development of LN. PATIENTS AND METHODS A retrospective case-control study of 127 patients with biopsy-prov...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 1990
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1990.tb05181.x